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The broader comparison between retatrutide and mazdutide or survodutide and tirzepatide shows how the next generation of multi-receptor agonists is expanding the landscape

While data from a RCT controls for many of the potential confounding factors, using data from non-primary endpoints requires caveats

Upregulation of Growth Factors BPC-157 enhances the expression of several key growth factors, including: VEGF (vascular endothelial growth factor) TGF- (transforming growth factor beta) FGF (fibroblast growth factor) EGF (epidermal growth factor) These factors collectively support cellular proliferation, matrix remodeling, and tissue regeneration

Bengtsson, A